Assessment of serum levels of bone morphogenetic proteins as sensitive biomarkers for early prediction of acute myocardial infarction.

Although acute myocardial infarction (AMI) is a life-threatening disease, rapid diagnosis may reduce mortality risk. Despite being highly specific for AMI, cardiac troponin I (cTnI) does not distinguish between the etiologically diverse of injury that be due to MI or non-MI causes. Bone morphogenetic proteins (BMPs), which are important modulators morphogenesis, members transforming growth factor-beta superfamily. This work intended evaluate utility 2 BMPs (BMP2 and BMP4) as diagnostic biomarkers AMI. study included 110 AMI patients 30 healthy volunteers. were subdivided into 39 without hypercholesterolemia diabetes mellitus (AMI HC DM), 33 with HC), 38 DM). BMP2 BMP4 levels assessed in all subjects. The results showed serum both significant elevation compared controls. In contrast, level only was significantly elevated DM those therefore able discriminate two subgroups. Notably, efficacy improved when combined. conclusion, good Nevertheless, had higher performance than discriminating from AUC 0.919 (p=0.001) highest PPV (100%), meanwhile, BMP4’s 0.891 (85.7%).